eLife16h
Membrane binding properties of the cytoskeletal protein bactofilin
The investigators studied the membrane-targeting sequence (MTS) of bactofilin A (BacA) in Caulobacter crescentus to explore its role in membrane binding and polymerization. They used various ...
eLife16h
Functional characteristics and computational model of abundant hyperactive loci in the human genome
Enhancers and promoters are classically considered to be bound by a small set of transcription factors (TFs) in a sequence-specific manner. This assumption has come under increasing skepticism as the ...
eLife2h
Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis
Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...
eLife23h
Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, USA ...
eLife1d
The promise and peril of comparing fluorescence lifetime in biology revealed by simulations
Fluorescence lifetime imaging microscopy (FLIM) excels over the widely used fluorescence intensity imaging by allowing the measurement of absolute signal levels, independent of sensor concentration.
eLife1d
Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance
This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...
eLife1d
Computational method pinpoints how cause-and-effect relationships ebb and flow over time
A new computer model can more accurately assess how causal relationships in complex real-world systems vary over time.
eLife2d
PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron
This important paper takes a novel approach to the problem of automatically reconstructing long-range axonal projections from stacks of images. The key innovation is to separate the identification of ...
eLife2d
Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
Penn Ovarian Cancer Research Center and Basser Center for BRCA, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States ...
eLife2d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, United States ...
eLife16h
Neuronal Development: Rethinking sensorimotor circuits
As you nod in agreement, or furiously shake your head side-to-side, your gaze stays almost perfectly stable. This remarkable ability to fix your eyes on whoever you may be agreeing (or disagreeing) ...
eLife1d
DendroTweaks: An interactive approach for unraveling dendritic dynamics
This manuscript introduces DendroTweaks, a useful web application and Python library that, compared to existing modeling tools, eases interactive graphical exploration, development, and validation of ...