A 75-year-old woman with rheumatoid arthritis and multiple myeloma was admitted to the hospital with abdominal pain. She had ...

Hereditary hemorrhagic telangiectasia (HHT) is characterized by extensive telangiectasias and arteriovenous malformations. The primary clinical manifestation is epistaxis that results in iron ...

Dr. Suellen S. Li (Medicine): A 47-year-old man was admitted to this hospital because of confusion and acute kidney failure. The patient had been well until 6 days before the current admission ...

For permission requests, please contact NEJM Reprints at [email protected] ...

Primary central nervous system (CNS) vasculitis is a rare, frequently misdiagnosed condition that affects the brain and spinal cord and is characterized by a variety of neurologic symptoms at ...

The 2024 Albert Lasker Award for Basic Medical Research recognizes Dr. Zhijian (James) Chen for his elucidation of how DNA stimulates immune responses.

The addition of zolbetuximab, an anti–claudin 18.2 antibody, to chemotherapy in gastric and gastroesophageal junction adenocarcinoma led to longer progression-free and overall survival than ...

In 1960, the discovery of the Philadelphia chromosome in patients with chronic myeloid leukemia (CML) opened the door to the development of insights on the role of genes in human cancers.

Allogeneic hematopoietic stem-cell transplantation is a curative therapy for a range of hematologic disorders. 1-3 Chronic graft-versus-host disease (GVHD) affects approximately half of transplant ...

The 2024 Lasker–DeBakey Clinical Medical Research Award recognizes Drs. Habener, Mojsov, and Knudsen, who developed GLP-1 medicines that have revolutionized the treatment of obesity.

In a pilot program in which 109,259 newborns were screened for metachromatic leukodystrophy, blood-spot samples were obtained for analysis and three newborns with MLD were identified, which made ...

For permission requests, please contact NEJM Reprints at [email protected] Clinicians routinely provide harm-reduction measures and anticipatory guidance for a range of complex health issues (e.g ...